REPROSAIT 4 U

Vulvovaginal Candidiasis

Vulvovaginal candidiasis is the name often given to Candida albicans infection of the vagina associated with a dermatitis of the vulva (an itchy rash). ‘Vaginal thrush’, and ‘monilia’ are also names for Candida albicans infection.

What causes vaginal discharge?

Most women notice from time to time that they have a discharge from the vagina. This is a normal process which keeps the mucous lining of the vagina moist. The discharge is usually clear but may dry on underclothes leaving a faint yellowish mark. This type of discharge does not require any medication even when quite profuse, as is often the case in pregnancy.

Vaginal discharge may also be due to microorganisms:

1. Vulvovaginal candidiasis (discussed here).
2. Trichomoniasis (due to a small parasite,Trichomonas vaginalis). This causes a fishy or offensive odour and yellow, green or frothy discharge.
3. Bacterial vaginosis (due to an imbalance of the amounts of bacteria which live in the vagina). This causes a thin, white/grey discharge and offensive odour.
4. Cytolytic vaginosis (due to an overgrowth of lactobacilli).

Excessive vaginal discharge may also be due to injury, foreign bodies and other causes of vaginitis.

What is the cause of vulvovaginal candidiasis?

About 20% of non-pregnant women aged 15 to 55 harbour Candida albicans in the vagina. Most have no symptoms and it is harmless to them. Overgrowth of Candida albicans causes a heavy white curd-like vaginal discharge, a burning sensation in the vagina and vulva and/or an itchy rash on the vulva and surrounding skin.

Candidal vulvovaginitis on a wet smear. Addition of potassium hydroxide here has made the hyphae more apparent. Arrows indicate budding yeast. (Courtesy of Pharmacia and Upjohn.)

Gram's stain of Candida organisms in vaginal secretions. Spores and hyphae (staining red/purple) as well as normal bacterial flora are seen. Arrows show buds and hyphae. (Courtesy of CDC.)

Oestrogen causes the lining of the vagina to mature and to contain glycogen, a substrate on which Candida albicans thrives. Lack of oestrogen in younger and older women makes vulvovaginal candidiasis much less common.

Overgrowth of Candida albicans occurs most commonly with:

1. Pregnancy
2. Higher dose combined oral contraceptive pill and oestrogen-based hormone replacement therapy
3. A course of broad spectrum antibiotics such as tetracycline or amoxiclav
4. Diabetes mellitus
5. Iron deficiency anaemia
6. Immunological deficiency e.g., HIV infection
7. On top of another skin condition, often psoriasis, lichen planus or lichen sclerosus.
8. Other illness

What are the symptoms?

Symptoms of vulvovaginal candidiasis, i.e., an overgrowth of Candida albicans, include:

1. Itching, soreness and/or burning discomfort in the vagina and vulva
2. Heavy white curd-like vaginal discharge
3. Bright red rash affecting inner and outer parts of the vulva, sometimes spreading widely in the groin to include pubic areas, inguinal areas and thighs.

These may last just a few hours or persist for days, weeks, or rarely, months.

Symptoms may sometimes be aggravated by sexual intercourse.

How is the diagnosis made?

The doctor diagnoses the condition by inspecting the affected area and recognising typical clinical appearance. The pH of the discharge tends to be less than 4.5 the diagnosis is often confirmed by a vaginal swab. In recurrent cases the swab should be repeated after treatment to see whether Candida albicans is still present.

It is best to avoid treatment for four weeks prior to a swab to improve the chance of positive culture.

Swab results can be misleading because the Candida albicans can be present without causing symptoms, and it can only be cultured if a certain amount is present. Swabs from outside the vagina can be negative, even when the yeast is present inside the vagina and there is a typical rash on the vulva. This is because the vaginal discharge has caused an irritant dermatitis, rather than the rash being directly due to infection.

Some women with recurring vulvovaginal symptoms appear to be hypersensitive to the organism (cyclic vulvovaginitis). In these cases it may be difficult for the laboratory to detect the yeast as a vigorous dermatitis has eradicated it.

In other cases, a different species of yeast i.e. a non-albicans candida is found. This is not likely to cause significant vulvovaginitis. Antifungal agents may not clear non-albicans candida from the vagina but luckily, it tends to disappear in time by itself.

Similar symptoms may occur from cytolytic vaginosis.

Treatment

Appropriate treatment for Candida albicans infection can be obtained without prescription from a chemist. If the treatment is ineffective or symptoms recur, see your doctor for examination and advice.

There are a variety of effective treatments for candidiasis. Topical antifungal pessaries or vaginal tablets are usually recommended – in mild cases a single treatment is all that is necessary. A cream formulation may be preferred. Oral antifungal medicines may be used if Candida albicans infection is severe or recurrent.

The creams can be used safely in pregnancy, but the tablets are best avoided.

Not all genital rashes are due to candida, so if treatment is unsuccessful it may because you have another reason for itching (pruritus vulvae) or burning (vulvodynia).

Recurrent Candidiasis

Occasionally Candida albicans infection persists despite adequate conventional therapy. In some women this may be a sign of iron deficiency, diabetes mellitus or an immune problem, and appropriate tests should be done.

It is now thought that women who experience recurrent vulvovaginal Candida albicans do so because of persistent infection, rather than re-infection. The aim of treatment in this situation is therefore to avoid the overgrowth of candida that leads to symptoms, rather than necessarily being able to achieve complete eradication or cure.

There is some evidence that the following measures can be helpful:

1. Cotton or moisture-wicking underwear and loose fitting clothing – avoid nylon pantyhose.
2. Soaking in a salt bath. Avoid soap – use a non-soap cleanser or aqueous cream for washing.
3. Apply hydrocortisone cream to reduce itching and treat secondary dermatitis affecting the vulva.
4. Treat with an antifungal cream before each menstrual period and before antibiotic therapy to prevent relapse.
5. A prolonged course of a topical antifungal agent is occasionally warranted (but these may themselves cause dermatitis or result in proliferation of non-albicans candida).
6. Oral antifungal medication (itraconazole or fluconazole) may be taken regularly and intermittently (e.g. once a month). The dose and frequency is quite variable, depending on the severity of symptoms. Oral antifungal agents may be unsuitable in pregnancy. They require a prescription.
7. Boric acid (boron) 600mg as a suppository at night may help to acidify the vagina and reduce the presence of yeasts (albicans and non-albicans candida).